The size is the only drawback, especially since I'm wanting it as an alternative to the (sizeable) DSLR! I wish there was something a little smaller that offered the same quality as the G6, but I haven't found anything. The Ixus 500 is tiny but flawed - too much CA, poor flash and allegedly rather fragile. The Sony P-150 (now to be replaced by the P-200) is very neat, but again not up to G6 quality. I've spent days reading reviews, and always come back to the A95 and the G6. The Oly C-7070 is a possibility, although it isn't yet out, but there's no size advantage over the G6.
I often put the G2 in a bubble-wrap bag rather than a fancy padded case, and it will then fit in my coat pocket. Even in a proper case it is a tenth of the weight (and size) of the 10D kit, so it satisfies most criteria. I've become used to the quality of the 10D, and I suspect that anything less than the G6 is likely to disappoint. And I really love the flip-out screen!